Similarly, we previously reported that SE-associated TMEM44-AS1 is immediately linked to SerpinB3, activating EGR1/IL-6 signaling and Myc; Myc immediately attaches to the TMEM44-AS1 SE being transcriptionally activated, aggravating the growth of gliomas through a positive feedback loop established with TMEM44-AS1 [116]. Here, PTGDR is linked to central nervous system cancer.