Histone acetyltransferase C/EBP occupies a SIRT7 SE, recruits BRD4 through H3K27 acetylation to upregulate SIRT7, and then epigenetically silences several metabolic regulators, including SOCS3 and ZBTB16, in HCC cells. This evidence concerns the gene BRD4 and hepatocellular carcinoma.