For example, the SEs of TP63, a lineage-specific master TF, are co-occupied with other CRC TFs (SOX2, KLF5, and TP63), and three SE constituents are required to transcribe TP63 as well as induce esophageal squamous cell carcinoma (ESCC) progression [74]. Here, KLF5 is linked to esophageal squamous cell carcinoma.