Histone acetyltransferase C/EBP occupies a SIRT7 SE, recruits BRD4 through H3K27 acetylation to upregulate SIRT7, and then epigenetically silences several metabolic regulators, including SOCS3 and ZBTB16, in HCC cells. The gene discussed is SIRT7; the disease is hepatocellular carcinoma.