MYC and acute lymphoblastic leukemia: For example, near the 3′-end of the MYC locus, SEs are locally amplified at distinct locations in cervical cancer, acute myeloid leukemia (AML), lung adenocarcinoma (LUAD), and acute lymphoblastic leukemia, and thus likely controlling MYC gene expression via germline-specific chromosomal looping [36–38].