In family NJ2639, we identified compound heterozygous variants (NM_019034: c.142 T > C;p.Tyr48His/c.343C > A;p.Pro115Thr) in RHOF in a patient presenting with microcephaly, global developmental delay, motor developmental delay and hypotonia (Table 2 and Supplementary Fig. S2). This evidence concerns the gene RHOF and Global developmental delay.