RUNX2 also regulates craniosynostosis-related genes, including skeletal tissue-enriched gene Pannexin3 (PANX3), skeletal tissue enriched gene matrix metalloproteinase 9 (MMP9), MMP13, and neural epidermal growth factor-like protein 1 (NELL1)13,14. The gene discussed is MMP9; the disease is craniosynostosis.