Patients with HER-2 with pre-operative MRI tumor (≤ 2 cm) or TNBC breast cancer with pre-operative MRI tumor (≤ 2 cm) were found to have MRI-ALN-NPV of 90.1%, and 92.3% (92.5% in pathologic tumor ≤ 2 cm), separately, which apparently increased the NPV of 77.7% of MRI in the general population (Table 4). The gene discussed is ERBB2; the disease is neoplasm.