Patients with HER-2 with pre-operative MRI tumor ≤ 2 cm or TNBC breast cancer with pre-operative MRI tumor ≤ 2 cm was found to have MRI-ALN-NPV of 90.1%, and 92.3%, respectively, which apparently increased the NPV of 77.7% of MRI in the general population. Here, ERBB2 is linked to breast cancer.