For two groups inoculated with wild-type SIPA1-expressing cells (BT549 and BT549/shSIPA1-SIPA1 cells), the tumor growth rate was significantly higher, and the tumor size was much larger than that xenografted with BT549/shSIPA1 and BT549/shSIPA1-dDBR, and the growth rate of BT549/shSIPA1-dDBR cells was almost equivalent to that of BT549/shSIPA1 cells (Fig. 6B, C). This evidence concerns the gene SIPA1 and neoplasm.