SIPA1 and neoplasm: Feeding the mice for another 10 days to observe tumor recurrence and pulmonary metastatic nodules at day 26, relapse was observed in BT549 group and BT549/shSIPA1-SIPA1 group (5 mice and 4 mice, respectively), whereas no recurrence was observed in BT549/shSIPA1 group and BT549/shSIPA1-dDBR group (Fig. 6F).