Case LYWS-1394 (Valentina Tabanelli) was a classic example of a lymphoid variant of hypereosinophilic syndrome (L-HES) in a 51-year-old man with a unilaterally enlarged tonsil and a 13-year history of eosinophilia and an aberrant CD4(+), sCD3(-) T-cell population in the peripheral blood. Here, CD4 is linked to hypereosinophilic syndrome.