When β2-M was analyzed as a continuous variable, multivariable-adjusted regression analysis demonstrated (adjustment for age, sex, weight, drinking status, smoking status, GFR, TC, Apo A1, Lp(a), ALT, ALB, TP, ALP, AST, GLU, urea, ChE, TBIL, TBA, HLP, hypertension, liver disease, and DM) that there was a 19% higher risk of CRC with each 1 mg/L increment in β2-M level (Model II, OR 1.19 [95% CI 1.01–1.4]). This evidence concerns the gene GPT and Hypertension.