Further, the recurrent SMARCB1-R37H mutation in the winged-helix DNA-binding domain, which causes severe intellectual disability and Kleefstra-like syndrome, also demonstrated hydrogen bonding with the carbonyl backbone of ARID1A-L2073 and Y2076 that is likely disrupted upon mutation (Extended Data Fig. 4e). The gene discussed is ARID1A; the disease is Intellectual disability.