Notably, genes such as ARID1B, SMARCA4 and SMARCA2 were among the top mSWI/SNF genes with most de novo missense and PTVs across all ASD + DD cases, with ARID1B having the most variants, followed by ANKRD11, KMT2A, and SCN2A (Extended Data Fig. 1m–n). This evidence concerns the gene ANKRD11 and dentin dysplasia.