GAPDH and cancer: Indeed, of the 15 proteins in the pan cancer model (Supplementary Table S27), three (GAPDH, phosphoglucose isomerase (PGI), and DLD) are important for energy metabolism and seven (ASL, WRS, NDPK, QSCN6, B4GalT1, lysophosphatidic acid phosphatase type 6 (ACP6), and BTD) are important for maintaining protein, lipid, nucleotide, or carbohydrate balance (Supplementary Table S33).