Recent studies have shown that TP53 mutations have prognostic value in GCB-DLBCL, but not in Non-GCB-DLBCL21, which could suggest that GCB-DLBCL is TP53-dependent while Non-GCB DLBCL is TP53-independent, and thus, could support the role of miR-129-3p, miR-129-5p, and miR-138-5p in GBC subtype. This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.