Among the most interesting downregulated genes targeted by more than one miRNA overexpressed in DLBCL, we identified FOXO1 and PTEN, involved in PI3K-Akt pathway26, predicted to be targeted by 5 (miR-182-5p, miR-183-5p, miR-135a-5p, miR-9-5p, and miR-9-3p) and 4 (miR-155, miR-320a, miR-205 and miR-182-5p) overexpressed miRNAs, respectively. This evidence concerns the gene PTEN and diffuse large B-cell lymphoma.