It is highly expressed in dopaminergic nigral neurones and its proteolytic cleavage by caspase 3 has been reported to be a key event in 6-OHDA induced dopaminergic neuronal death in cellular and animal models of PD, including rescue of N27 cells and TH+ mesencephalic neurones by PKCδ siRNA and loss of function induced by PKCδ gene mutations58. This evidence concerns the gene PRKCD and Parkinson disease.