Compared to surrounding liver tissues, 2817 genes were upregulated (fold change, >1.5; P adj < 0.05) in c-MET-high/TP53-null HCC samples, among which 521 genes were also upregulated in c-MET/sgp53 mouse HCCs (Fig. S6A). The gene discussed is TP53; the disease is hepatocellular carcinoma.