Gene expression analysis demonstrated the upregulation of HCC-related genes, including Afp, Gpc3, and Prom1, as well as genes associated with cell proliferation, such as Ccnb1, Ccne1, Cdk6, Bub1, and Mki67 in c-MET/sgp53 tumors (Fig. S3). Here, GPC3 is linked to hepatocellular carcinoma.