Moreover, Chung et al. also indicated that AIM2 has a crucial function in glomerular epithelial cell proliferation and modulates ALR-mediated inflammation during glomerulonephritis, indicating that the AIM2-dependent pyroptotic pathway is a potential therapeutic target for proliferative glomerulonephritis and other kidney diseases [109]. Here, AIM2 is linked to proliferative glomerulonephritis.