PTPN2 and neoplasm: To explore whether the Compound 182-mediated repression of tumor growth might reflect the inhibition of PTP1B/PTPN2 not only in T cells, but also in different immune subsets, we sought to determine if deleting PTPN2 throughout the entire immune system might elicit more pronounced anti-tumor immunity; we focussed on PTPN2 as the effects of deleting PTPN2 in T cells on immune cell recruitment were more pronounced when compared with the deletion of PTP1B in T cells.