The deletion of PTPN2 in T cells not only promoted the activation and cytotoxic potential of tumor-infiltrating/resident T cells (as reflected by IFNγ, TNF and GZMB levels), but also enhanced STAT-1 signaling in AT3-OVA tumor cells, the expression of Cxcl9 and the recruitment of T cells. The gene discussed is TNF; the disease is neoplasm.