PTPN2 and metastatic neoplasm: At present two PTP1B/PTPN2 inhibitors, ABBV-CLS-484 (Fig. S1) and ABBV-CLS-579, are in phase I clinical trials (NCT04417465, NCT04777994) for patients with locally advanced or metastatic tumors and are being tested alone and in combination with α-PD-1.