Beyond promoting the infiltration and/or expansion of central memory and effector/memory T cells and the accumulation of cytotoxic CD8+ T cells in AT3-OVA mammary tumors, Compound 182 also increased the accumulation of natural killer (NK) cells and B cells that can promote anti-tumor immunity (Fig. 3c); this was also evident in MC38 and AT3 tumors (Fig. 4c, f). The gene discussed is CD8A; the disease is breast cancer.