PTPN2 and neoplasm: We noted that although the deletion of PTPN2 in AT3-OVA tumors did not significantly affect tumor growth (Figs. S13–14), the deletion of PTPN2 in AT3 cells markedly repressed tumor growth (Fig. 8a; Supplementary Fig. 13) and this was accompanied by a marked increase in TILs, including effector T cells and NK cells and the expression of STAT-1 target genes, including Cxcl9, Cxcl10, Cd274 and H2k1 (Fig. 8b, c).