Given that the administration of Compound 182 to tumor-bearing mice was accompanied by the pronounced recruitment of NK cells, which can have both direct cytotoxic effects, as well indirect anti-tumor effects through IFNγ-dependent T cell recruitment55, we also assessed if Compound 182 might at least in part act by inhibiting PTP1B or PTPN2 in NK cells. This evidence concerns the gene PTPN2 and neoplasm.