SERPINA1 and breast cancer: To ascertain whether these enrichments were driven by effects on VM, we used our orthogonal acLDL RNA-Seq dataset (Fig 6B) and our endo-high 4T1-T scRNA-Seq dataset, finding enrichment of breast cancer (Fig 6B and 6C) and GBM (Fig S6C) AAT resistance genes in acLDL high or endo-high tumor cells, independently implicating VM in AAT resistance.