Moreover, FOXC2 knockdown significantly impeded acLDL uptake in VM-proficient cell lines 786-O (Renal)20, H446 (SCLC)18 and U87-MG (Glioma)21 (Fig 3F and S3G), suggesting that the effects of Foxc2 are not restricted to breast cancer cell lines. This evidence concerns the gene FOXC2 and central nervous system cancer.