As in 4T1-T, endo-high cells within Axitinib treated tumors showed enrichment for FOXC2-targets (Fig 5H), ECM, and hypoxia gene sets (Fig 5I) indicating that exposure to hypoxia in vivo through AAT promotes VM and the acquisition of an ECM-producing quasi-endothelial state in tumor cells. This evidence concerns the gene SERPINA1 and neoplasm.