Finally, FOXC2 mRNA levels were significantly upregulated in VM-proficient non-neuroendocrine (non-NE) tumor cells isolated from small cell lung cancer circulating tumor cell-derived explants (SCLC CDXs), when compared to their VM-deficient neuroendocrine counterparts (Fig 2H)13. The gene discussed is FOXC2; the disease is small cell lung carcinoma.