This RCT aims to compare the effects of 8 weeks of EH (simulated high-altitude at 3.000 m), combined or not with an LCD (40% of energy from carbohydrates) on glycemic and lipid profiles, HIF1-α, C-reactive protein, blood pressure, body composition and cardiorespiratory parameters in patients with T2DM. Here, HIF1A is linked to type 2 diabetes mellitus.