TP53 and adenocarcinoma: Based on the TCGA database, TTN expression was significantly associated with the clinical stage (normal vs. Stage 1, p < 0.05; normal vs. Stage 4, p < 0.05), node metastasis (normal vs. N1, p < 0.05; N1 vs. N2, p < 0.05), histological type (normal vs. adenocarcinoma, p < 0.05), race (Caucasian vs. Asian, p < 0.05; African‐American vs. Asian, p < 0.05) and TP53 mutation (normal vs. TP53 mutation, p < 0.05) (Figure 2A–F).