CRP and rheumatoid arthritis: Significant downregulation of miRNA-330-3p was observed in RA patients with positive anti-CCP (p<0.01) compared to negative anti-CCP, with ESR >31(p<0.0001) compared to ESR<31 and with CRP>14 (p<0.002) compared to CRP<14, as shown in Fig 6B.