Significant downregulation of miRNA-10a-5p was also observed in RA patients with positive anti-CCP (p<0.04) compared to negative anti-CCP, with ESR >31(p<0.001) compared to ESR<31 and with CRP>14 (p<0.01) compared to CRP<14, as shown in Fig 4B. Here, CRP is linked to rheumatoid arthritis.