Significant downregulation of said miRNA was also observed in RA patients with positive anti-CCP (p<0.0001) to compared negative anti-CCP, with ESR >31(p<0.0003) compared to ESR<31 and with CRP>14 (p<0.009) compared to CRP<14, as shown in Fig 7 However, comparatively a non significant downregulated expression of miRNA-19b was observed in different age (p<0.06) and gender groups (p<0.68) of RA patients (Fig 7B). Here, CRP is linked to rheumatoid arthritis.