Of all parameters measured, the greatest mean difference between T1D and CTR (without a significant age association) was substantially increased frequency of CXCR3 expression among naive CD8+ T cells (Figure 5), due to increased CXCR3lo and decreased CXCR3– subset percentages (Figure 6, A and B, and Supplemental Figure 14, A and B). Here, CXCR3 is linked to type 1 diabetes mellitus.