CD4 and type 1 diabetes mellitus: Despite significantly increased frequency of PD-1+ cells within naive CD4+, naive CD8+, and CD8+ Temra subsets from T1D participants (Figure 6, F–H, and Supplemental Figure 14, F–H), PD-1 expression intensity (MFI) was decreased in T1D participants on the majority of subsets analyzed: CD4+ Tem, CD4+ Temra, CD4+ Tcm, and CD8+ Tcm (Figure 6, I–L, and Supplemental Figure 14, I–L).