Younger age of onset has also been associated with the highest risk HLA-DR3/4 diplotype (5), a prominent T and B cell insulitic lesion in the pancreas of T1D organ donors (9, 10), a bias toward IFN-γ:IL-10 T cell autoreactivity (64), and more acute clinical loss of endogenous C-peptide (29). Here, IFNG is linked to type 1 diabetes mellitus.