Analyses of open databases (22) for a potential association of COL18A1 mRNA levels with survival of patients with BC showed that high COL18A1 expression is significantly associated with poor prognosis in patients with high-grade BCs but not in unclassified patients or in those with low-grade tumors (Figure 1, J–O, and Supplemental Figure 4, A–F). Here, COL18A1 is linked to breast cancer.