In the phase II clinical trial CAIRO7 (NCT05092880), expected completion date October 2028, elderly or frail patients with CRC and unresectable liver metastases are randomized to receive a liver ER with holmium-166 microspheres as a first-line treatment or combined capecitabine and anti-VEGF treatment. The gene discussed is VEGFA; the disease is colorectal carcinoma.