Membrane metallo-endopeptidase-like (MMEL1 1) is most high ranked by Open Targets, also known as neprilysin 2, while MMEL1 is a membrane-bound metalloprotease that has been implicated in a range on autoimmune disease, including RA (Mathebula et al. 2022). This evidence concerns the gene MMEL1 and rheumatoid arthritis.