NLRP3 and diabetes mellitus: Ins (1.5 IU/animal) significantly (P < 0.0001) reduced renal expression of NF-κB (Fig. 6A), IL-1β (Fig. 6B), and NLRP3 (Fig. 6C) by ~ 67.5%, 63.7%, and 65.3%, respectively, compared to DM group.