The occurrence of subclinical large vessel vasculitis, far from being considered an unusual or only a late complication of PMR, is evidenced in up to 20% of patients [7, 40] and a recent meta-analysis, which is in line with our findings [40] has found that fever, and not CRP and ESR, is strongly associated (OR 1.83, 0.90–3.71) with GCA in PMR. The gene discussed is CRP; the disease is Large vessel vasculitis.