As low levels of desmin appeared to be associated with sarcomere damage in a rat model of diabetes mellitus (95) and alpha-actinin staining showed disrupted sarcomere/costamere/z-disc striations in desmin-null mice (96), it is coherent that the improved levels of desmin in the AAV9-treated Smn2B/− mice result in improved sarcomere structure, although higher resolution microscopy is required to confirm this. The gene discussed is DES; the disease is diabetes mellitus.