MTOR and dilated cardiomyopathy: Most of the significantly enriched ‘canonical pathways’ common to both mouse models have also been implicated in SMA, such as EIF2 signaling (23), mitochondrial dysfunction (24) and mTOR signaling (37), but of particular interest was the significant enrichment of ‘dilated cardiomyopathy’ and the ‘dilated cardiomyopathy signaling pathway’ in both mouse models of SMA.