Lung cancer patients were found to have lower bacterial diversity, with the genera Acidovorax, Klebsiella, Rhodoferax, and Anaerococcus significantly enriched in smokers with squamous cell lung carcinoma.63 Further, the presence of genera Acidovorax, Klebsiella, Rhodoferax, Comamonas, and Polarmonas was highly associated with p53 mutations.63 Researchers have seen increases in members of the Proteobacteria phylum in lung cancer patients, but the significance of this association varies by study. Here, TP53 is linked to lung cancer.