S100A8/9-high neutrophils, identified from bulk-RNA deconvolution, are known to act as an endogenous ligand for TLR-431 and the receptor for advanced glycation end product (RAGE,32 and have been negatively correlated with sepsis recovery,20 as well as being implicated in SARS‐CoV‐2 induced viral pneumonitis.33 We observed a heightened abundance of these 2 cell types in both the pre- and postoperative samples of pneumonia patients, implying that the functional effects of S100A8/9-high neutrophils may predispose to postoperative pneumonia. This evidence concerns the gene S100A8 and pneumonia.