SLC9A3 and adenoma: A variety of studies have demonstrated that many transporters and channels, such as sodium hydrogen exchanger 3 (NHE3), the cystic fibrosis transmembrane conductance regulator (CFTR), and downregulated in adenoma (DRA), act in concert to regulate the process of fluid secretion and acid–base secretion in the digestive tract (Seidler and Nikolovska, 2019).