Besides, increasing NAD + level in rat cardiomyocytes through overexpression of nicotinamine mononucleotide adenylyltransferease (NMNAT) safeguards against cardiac hypertrophy via Sirt6-mediated pathway, suggesting that NMNAT2 overexpression would be unable to stop AngII-induced cardiac hypertrophy without Sirt6 intervention. This evidence concerns the gene NMNAT1 and cardiac hypertrophy.