SIRT6 and atherosclerosis: Recent studies found that isoliquiritigenin (ISL), extracts from traditional Chinese medicine licorice flavonoids, alleviates NLRP3-mediated vascular endothelial cell pyroptosis in HUVECs through Sirt6-dependent signaling cascades, and Sirt6 could be a promising target for ISL in the treatment of atherosclerosis (He et al., 2023).