In a similar manner, downregulation of endothelial Sirt6 increases vascular cell adhesion molecule1 (VCAM1) as well as intercellular adhesion molecule1 (ICAM1) expression and contributes to the recruitment of inflammatory cells under atherosclerosis condition, resulting in the accumulation of atherosclerotic lesions in the vascular system. This evidence concerns the gene SIRT6 and atherosclerosis.