Tan et al., 2021 found that curcumin promotes cholesterol efflux via miR-125a-5p/Sirt6 axis in macrophages to prevent atherosclerosis Zheng et al., 2021 found that Sirt6/ACE2 signaling pathway prevents cholesterol crystal-induced endothelial dysfunction in HUVECs. Their newest data discovered endothelial Sirt6 overexpression corrects endothelial cell dysfunction (Wang et al., 2023). Sirt6 also influences the modulation of total and LDL cholesterol (Raj et al., 2020), which again corroborates the concept that Sirt6 intervenes in the process of atherogenesis via regulating lipid metabolism. This evidence concerns the gene SIRT6 and endothelial dysfunction.