SIRT6 and acute myocardial infarction: In supporting of this, myocardial hypoxia/reoxygenation (H/R)-induced injury is significant in mediating the pathogenesis of acute myocardial infarction, and Sirt6 suppresses cell death via NF-kB signaling cascade in myocardial H/R-induced injury (Cheng et al., 2016).