For example, a paper claimed that Sirt6 inhibition exacerbates diabetic cardiomyopathy by intensifying oxidative stress and inflammation in H9c2 cell line (Huang et al., 2021) whereas Sirt6 overexpression prevents the heart from developing obesity-mediated diabetic cardiomyopathy (Kanwal et al., 2019). The gene discussed is SIRT6; the disease is obesity due to melanocortin 4 receptor deficiency.