However, in 2023, a new study argued that xanthenone administration leads to upregulation of Sirt6 via miR-122; Sirt6 upregulation activates ACE2 levels and decreases its substrates angiotensin II, subduing the rampaging storm of inflammatory cytokines and elevated levels of cardiac biomarkers and attenuating myocardial infarction injury (Abdel-Nasser et al., 2023). The gene discussed is SIRT6; the disease is myocardial infarction.