A latest study published in 2023 discovered that hepatic-specific depletion of Sirt6 in mice has been demonstrated to exhibit hepatic fibrosis (Dong, 2023), although one limitation of this experiment is that it was conducted in in vivo models of hepatic fibrosis instead of cardiac fibrosis, it arose researchers’ interests in the regulatory function of Sirt6 in cardiac fibrosis and enlightened more people to devote their time into this direction. This evidence concerns the gene SIRT6 and Hepatic fibrosis.