It is hard to translate experimental findings to applicable clinical treatments; however, Zheng et al., 2022 found that Rhaponticum carthamoides (Rha) attenuates myocardial ischemia injury and suppresses oxidative stress in rat myocardial tissue; Rha upregulates Sirt6 levels whereas inhibition of Sirt6 abrogates the positive effect of Rha on ROS levels, suggesting that Rha enjoys a cardioprotective effect on myocardial injury through a Sirt6-dependent signaling pathway. The gene discussed is SIRT6; the disease is myocardial ischemia.