This contention is testified by the fact that Sirt6 expression is reduced in the glomeruli of patients with hypertensive nephropathy, and Sirt6-dependent NRF2-HO1 signaling pathway relieves AngII-induced podocyte apoptosis, which leads to attenuation of hypertensive nephropathy (Fan et al., 2021). The gene discussed is NFE2L2; the disease is hypertensive nephropathy.