Besides, recent results showed that Sirt6 protects vascular endothelial cells from AngII-induced oxidative stress through upregulation of Nrf2/ARE signaling cascade, suggesting Sirt6 functions as a promising therapeutic target for the treatment of hypertension related to aberrant endothelial cell function (Yang et al., 2019). The gene discussed is SIRT6; the disease is Hypertension.