In this research, network pharmacology and combined bioinformatics were used to analyze the targets of traditional Chinese medicine extracts quercetin and kaempferol, construct and screen the interaction network between drugs and CRC pathogenic genes, and finally screen three prognostic related genes: CDKN2A, SERPINE1, and MMP3 74-79. The gene discussed is SERPINE1; the disease is colorectal carcinoma.