Formerly studies showed that these two components have similar effects, there is also overlap between targets, and both can inhibit the role of P-gp to reverse tumor drug resistance and inhibit some signal pathways, such as P13K/AKT signaling pathway, EGFR signaling pathway, mTOR signaling pathway, MAPK signaling pathway, Jak-STAT signaling pathway, and NF-κB signaling pathway et al. Thus, there is reason to believe that quercetin and kaempferol can exert a synergistic effect at the level of molecular pathways. This evidence concerns the gene NFKB1 and neoplasm.