Additionally, sustained activation of protein kinase B in liver cancer phosphorylates phosphoenolpyruvate carboxykinase 1 (PCK1) in the cytoplasm, and phosphorylated PCK1 promotes SREBP-1 to leave the endoplasmic reticulum and activate SREBP-1, thereby promoting tumor growth 63. The gene discussed is SREBF1; the disease is neoplasm.