SREBF1 and hepatocellular carcinoma: Oridonin reduced the expression of SREBP-1 mRNA and protein in colorectal cancer cells, whereas Zhiheshouwu extract reduced fatty acid production via inhibiting SREBP-1 and its downstream factor stearyl-CoA dehydrogenase1 (SCD1) in hepatocellular carcinoma (HCC) cells thereby affecting fatty acid formation in tumors 86, 87.