Through univariate Cox regression analysis, five angiogenesis-related DEGs (SCG2, SPHK1, TNNI3, JAG2, and TIMP1) and six NETs-related DEGs (CD36, TIMP1, NOS3, TERT, SERPINE1, and BGN) were identified with prognostic values (Fig. 2C) (Fig. 2D), serving as risk genes for the prognosis of COAD patients. This evidence concerns the gene SCG2 and colon adenocarcinoma.