Through univariate Cox regression analysis, five angiogenesis-related DEGs (SCG2, SPHK1, TNNI3, JAG2, and TIMP1) and six NETs-related DEGs (CD36, TIMP1, NOS3, TERT, SERPINE1, and BGN) were identified with prognostic values (Fig. 2C) (Fig. 2D), serving as risk genes for the prognosis of COAD patients. The gene discussed is SERPINE1; the disease is colon adenocarcinoma.