SPHK1 and colon adenocarcinoma: Through univariate Cox regression analysis, five angiogenesis-related DEGs (SCG2, SPHK1, TNNI3, JAG2, and TIMP1) and six NETs-related DEGs (CD36, TIMP1, NOS3, TERT, SERPINE1, and BGN) were identified with prognostic values (Fig. 2C) (Fig. 2D), serving as risk genes for the prognosis of COAD patients.