IL1R1 and anxiety disorder: Various other genes have been implicated in the efficacy of CBT/iCBT in treating anxiety disorders, such as Glutamate Receptor, Ionotropic Kainate 4 (GRIK4), Hypocretin/hypocretin receptor 1 (HCRTR1), and Interleukin 1 Receptor Type 1 (IL1R1).