Researchers observed that GRIK4 rs1954787 influences CBT/iCBT efficacy in children with anxiety disorders, HCRTR1 rs2271933 affects CBT/iCBT efficacy in panic disorder/agoraphobia (PD/AG) patients121, and methylation of IL1R1 cg06943668 increases following CBT/iCBT in PD patients122. This evidence concerns the gene IL1R1 and anxiety disorder.