LEP and gestational diabetes: Figure 1. represents the proposal algorithm we have adopted in order to support our hypothesis and provide further insight to the role of leptin in GDM and its impact on placental nutrient availability compared to other pregnancy complications related to hypoleptinemia, such as fetal growth restriction (65–67) and spontaneous miscarriage in the first pregnancy trimester (69, 70), as mentioned in the previous section (see Table 1 for more details).