IARS1 and neoplasm: Likewise, when limiting results to the seven tumor types highlighted by Nassar and colleagues (8), where they observed significantly greater TMB-H frequency in four of seven tumor types for self-reported non-European versus European patients in the Dana-Farber Cancer Institute (DFCI) tumor-only CGP cohort (Supplementary Table S9), only one of seven tumor types had significantly higher frequency of TMB-H or IRS-H in the SCMD for non-European versus European patients (IRS-H in EGCs; Fig. 3C; Supplementary Table S9).