CD274 and gastric cancer: In addition, interpretation of clinically relevant cutoffs show substantial variability in real world practice, particularly using the CPS scoring system at lower cutoffs, as demonstrated in a recent study of the companion diagnostic PD-L1 for gastric cancer (22C3 PD-L1 IHC with the CPS system), where Fernandez and colleagues showed an overall percent agreement of only 30% using the approved CPS <1 versus ≥1 threshold when 14 pathologists evaluated the same IHC slide (28).