Hence, here, we first demonstrated that in both the previously reported NSCLC cohort, where PD-L1 IHC expression was evaluated by TPS (n = 276), and in a cohort of 221 tumors from 23 tumor types [most frequent EGC (35.3%); only 2.3% NSCLC] with accompanying PD-L1 IHC expression by 22C3 combined positive scoring (CPS), PD-L1 qTP and IHC expression were only moderately correlated (Pearson r = 0.64 and r = 0.62, respectively; both P < 0.001; Fig. 2B and C), despite the highly correlated (Pearson r = 0.96 and 1,757x linear range) nature of PD-L1 gene expression by qTP versus qRT-PCR (Fig. 2A). Here, CD274 is linked to non-small cell lung carcinoma.