On the other hand, activated c-Kit activates the downstream Wnt/β-catenin signaling pathway (141), and Wnt is abundantly expressed in colorectal tumour cells (142), ultimately activating the β-catenin signaling pathway in mast cells in colorectal tumours, while β-catenin stimulates protease maturation and expression in mast cells, and activated β-catenin mediates bone marrow-derived mast cell support of colon cancer (143). Here, KIT is linked to colorectal neoplasm.