For obesity, diabetes, hypertension and hyperlipidemia, the AUC values of S100A8 were 0.925 (95% confidence interval: 0.783–1.0), 0.875(95% confidence interval: 0.679–1.0), 0.96 (95% confidence interval: 0.849–1.0), 0.75 (95% confidence interval: 0.541–0.959), respectively (Figures 10E–H). This evidence concerns the gene S100A8 and obesity due to melanocortin 4 receptor deficiency.