They also observed that the CD4+ TSCM cells of SLE patients can differentiate into TFH cells through BCL6, CXCR5, PD1, ICOS, LEF1, TCF-1, and IL-21 (as TFH cell inducer) gene overexpression, and BLIMP-1 gene encoding downregulation, leading to pathogenic auto-Ab formation (38). This evidence concerns the gene CD4 and systemic lupus erythematosus.