However, a new subset of memory T cells has been recently recognized during the investigation of the graft-versus-host disease translational model, which possesses features of both TCM and TEM cells including lymphoid homing and effector role performance through secreting effector cytokines like interleukin-2 (IL-2) and interferon-gamma (IFN-γ) named T memory stem cell (TSCM) cells. Here, IL2 is linked to graft versus host disease.