For example, increased intraepithelial CD8 T cell count in the tumour microenvironment is associated with prolonged survival in colorectal, ovarian and endometrial cancer (88–90) and the intraepithelial subpopulation of CD8 T cells was found to be increased in ectopic lesions in the early secretory phase when compared to matched eutopic and healthy endometrium (32). This evidence concerns the gene CD8A and neoplasm.