CTLA4 and autoimmune disease: So far, AITD (182), SLE (183), diffuse cutaneous systemic sclerosis (184), MG (185), celiac disease (186), and allergic asthma (187) do not have the results of clinical trials for CTLA-4-Ig, but the clinical study indicated that a higher level of sCTLA-4 was found in the serum of the above autoimmune disease patients.