Insulin resistance is a major feature in T2DM development (Gerich, 2003) and may be caused by an insulin signalling defect, inflammatory cytokines (Halim and Halim, 2019), lipotoxicity (Kelly et al., 2019; Poznyak et al., 2020), glucose transporter defect, amyloid formation for β-cell dysfunction (Eizirik et al., 2020), OS (Dos Santos et al., 2019), mitochondrial dysfunction, excess fatty acid, or lack of the cretin effect (Galicia-Garcia et al., 2020). This evidence concerns the gene INS and Insulin resistance.