HMOX1 and type 2 diabetes mellitus: In particular, It may alleviate T2DM by improving the phosphoinositide 3-kinase (PI3K)/Phosphorylated protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK3β) pathway, and activating nuclear factor erythroid-2/heme oxygenase-1(Nrf2/HO-1) pathway.