Administration of GLP-1RA, liraglutide can be beneficial in preventing and/or managing Type II diabetes-associated reproductive complications, significantly reversing the deleterious diabetic impacts and improving reproductive function through GLP-1/kiss1/leptin/GnRH and TGF-β/Smad pathways indicating additional benefits for GLP-1RAs other than dealing with diabetes. This evidence concerns the gene KISS1 and type 2 diabetes mellitus.