STAT3 and breast cancer: The CCD at the amino terminus has been implied to be essential for protein-protein interaction, receptor recruitment, and tyrosine phosphorylation of STAT3.33 Intriguingly, a recent study by Zhou et al reported that a lncRNA-encoded polypeptide ASRPS could bind to the CCD of STAT3 and downregulate STAT3 phosphorylation, thereby inhibiting angiogenesis in breast cancer.34 Thus, these results indicate that effects of the CCD on STAT3 activity might depend on the specific tissue context and different interacting molecules.