Consistently, RT‒qPCR results showed that K17 KO also downregulated the mRNA levels of the proliferation markers K17, K16, PCNA, Cyclin D1 (Supplementary Figure 7A) and key enzymes (GLUT1, PFKM, LDHA, HK2, PKM2, ENO1 and PGK1) in the IMQ-induced psoriasis-like model (Figure 6E). The gene discussed is HK2; the disease is psoriasis.