Moreover, Ki67 expression (Figure 6I) and the mRNA levels of proliferation markers K17, K16, PCNA, Cyclin D1 (Supplementary Figure 7B) and key enzymes (GLUT1, PFKM, LDHA, HK2, PKM2, ENO1 and PGK1) were also decreased in epidermal KCs of the IMQ-induced psoriasis-like model with local application of BI-D1870 (Figure 6J). This evidence concerns the gene PCNA and psoriasis.