We found that when the phosphorylation of K17-Ser44 was blocked with ENO1 siRNA, ENOBlock or BI-D1870, the punctate pattern of K17 was dramatically eliminated in KCs with the K17 overexpression plasmid pEGFP-N1-K17 (Figure 5D), and the level of phosphorylation of K17-Ser44 was also decreased in both the nucleus and cytoplasm of KCs (Figure 5E and 5F). The gene discussed is TBCE; the disease is dry eye syndrome.