Finally, by establishing a mouse model of IMQ-induced psoriasis, we found that local application of ENOBlock (Figure 3I and 3J) or ENO1 siRNA (Supplementary Figure 4A and 4B) relieved the symptoms of erythema and scaling, reduced the thickness of the epidermis (Supplementary Figure 4C and 4D), downregulated Ki67 expression (Figure 3K and Supplementary Figure 4E-G) and inhibited mRNA expression of proliferation-related genes such as K17, K16, PCNA and Cyclin D1 (Supplementary Figure 4H and 4I). Here, PCNA is linked to psoriasis.