For examples, genistein, which is a soybean isoflavone existing in Chinese herbal medicine such as Pueraria lobata, Vietnamese Sophora root and Net Cliffbean, combined with arsenic trioxide to significantly shift the balance of Bax/Bcl-2 proteins and thus increased the expression of caspase-3 and caspase-9, leading to efficient tumor inhibition in hepatocellular carcinoma (HCC). The gene discussed is CASP3; the disease is hepatocellular carcinoma.