When combined with paclitaxel, the Nur77/ΔDBD gene efficiently inhibited the paclitaxel efflux induced by P-gp and decreased anti-apoptotic Bcl-2 expression and increased pro-apoptotic protein expression, thus improving the antitumor effects of paclitaxel on paclitaxel-resistant hepatoma 137. This evidence concerns the gene BCL2 and hepatocellular carcinoma.