EGFR and head and neck cancer: For examples, apigenin, which is a flavone that existed in celery and Chinese medicine Rhizoma polygoni cuspidati, was combined with epidermal growth factor receptor (EGFR) inhibitor cetuximab to synergistically down-regulate p-EGFR, p-Akt, p-STAT3 and Cyclin D1 in head and neck cancers.