LY2624587, a fully humanized CXCR4 monoclonal antibody, can effectively block the binding of CXCL12 and CXCR4, induce dose-dependent cell death in human hematological cancer cells in vitro and in vivo, and is used for the treatment of hematological malignancy patients 159, 160. Here, CXCR4 is linked to hematologic disorder.