LY2624587, a fully humanized CXCR4 monoclonal antibody, can effectively block the binding of CXCL12 and CXCR4, induce dose-dependent cell death in human hematological cancer cells in vitro and in vivo, and is used for the treatment of hematological malignancy patients 159, 160. This evidence concerns the gene CXCR4 and hematopoietic and lymphoid cell neoplasm.