CXCR4 and malignant colon neoplasm: Furthermore, onbaekwon (OBW), a complex herbal formulation, inhibited the expression of CXCR4 in colon cancer cells, breast cancer cells and other cells in a concentration- and time-dependent manner by blocking the endogenous activation of NF-κB, and abolished CXCL12-induced invasion of colon cancer cells 175.