Leucine-rich repeats containing 4 (LRRC4), a putative glioma suppressive gene, significantly inhibited the proliferation, chemotaxis and invasion of human glioblastoma U251 cell line induced by CXCL12/CXCR4/ERK1/2/AKT 59. The gene discussed is CXCR4; the disease is central nervous system cancer.