In endometrial cancer, CAFs activated PI3K/AKT and MAPK/ERK signals in a paracrine-dependent manner, or increased MMP-2 and MMP-9 secretion in an autocrine-dependent manner through CXCL12-CXCR4 axis, thus promoting the invasion and metastasis of endometrial cancer 69. This evidence concerns the gene MAPK1 and endometrial cancer.