Further studies revealed that the CXCL12-CXCR4 signaling axis upregulated the expression of integrin αvβ6 by increasing ERK phosphorylation and subsequent Ets-1 transcription factor activation, leading to the directional transfer of human CRC cell line Caco-2 and the development of CRC 65. This evidence concerns the gene MAPK1 and colorectal carcinoma.