In contrast, cancer cells with high levels of SLC7A11 (SLC7A11high) have been observed to accumulate intracellular cystine when glucose levels are low, draining the cellular NADPH pool and leading to the aberrant accumulation of intracellular disulfides and subsequently to disulfidptosis, a previously uncharacterized form of cell death that differs from apoptosis and ferroptosis89, 90. The gene discussed is SLC7A11; the disease is cancer.