GPX4 and injury: However, in sepsis-associated acute lung injury (SI-ALI), neutrophil extracellular traps (NETs) activate the TLR9/MyD88/NF-κB pathway to upregulate METTL3 expression, which induces the m6A methylation of GPX4 mRNAs, inhibiting GPX4 expression and increasing the ferroptosis of alveolar epithelial cells169.