KMT2B activated the transcription of riboflavin kinase (RFK) by enhancing the trimethylation of H3K4, which subsequently accelerated tumor necrosis factor-α (TNF-α)/NADPH oxidase 2 (NOX2) axis activation to promote ferroptosis during myocardial ischemia/reperfusion injury205. Here, RFK is linked to myocardial ischemia.