Similar to METTL3, METTL14, another m6A methyltransferase, installs m6A modification on the 5'UTR of SLC7A11 mRNAs to facilitate their degradation in a YTHDF2-dependent manner, and hypoxia induces the downregulation of METTL14 by regulating HIF-1α levels, thus protecting hepatocellular carcinoma (HCC) cells from ferroptosis161. The gene discussed is METTL3; the disease is hepatocellular carcinoma.