Lee et al. demonstrated that FADS1 and elongation of very long-chain fatty acid protein 5 (ELOVL5) were required to maintain intracellular levels of AA and AdA, and the expression of FADS1 and ELOVL5 was found to be frequently inhibited by an increase in the DNA methylation marks on at their promoter/enhancer regions in intestinal-type gastric cancer cells (GCs), which resist ferroptosis118. Here, FADS1 is linked to gastric cancer.