In contrast, tripartite motif-containing protein 7 (TRIM7) directly binds to and ubiquitinates NCOA4 in a K48-linked polyubiquitylation manner, facilitating the degradation of NCOA4 and reducing the ferritinophagy and ferroptosis of human glioblastoma cells63. The gene discussed is TRIM7; the disease is glioblastoma.