IHC staining of USP14 in our FUSCC cohort showed that the IHC score was significantly higher in carcinoma tissues than normal tissues, and the expression of SDC2 was significantly higher in the High-USP14 group (IHC score > 4) than the Low-USP14 group of GC tumor specimens (Fig. 7J and 7K). The gene discussed is SDC2; the disease is gastric cancer.