While TPO administration failed to sufficiently elevate platelet counts of Creg1pf4-cre mice to prevent the thrombocytopenia, the number of platelets in Creg1pf4-cre mice compared with that before TPO injection (821.3 ± 32.8 × 109/L vs. 633.3 ± 26.2×109/L, respectively) (Supplementary Figure 3D). The gene discussed is TPO; the disease is Thrombocytopenia.