Severe neurological manifestations, such as coma 96, as well as levels of TNF-α, IL-6, IL-8 and granulocyte colony stimulating factor (G-CSF) 32, kynurenine and kynurenic acid 97 and angiopoietin-2 98 are increased in the CSF being associated with persistent neurocognitive sequelae of Ugandan child recovering from CM. The gene discussed is CSF3; the disease is Coma.